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Dr. H.B. Brouwers
Neurochirurg

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Dr. H.B. Brouwers - Neurochirurg

“Het is een voorrecht dit vak te mogen uitoefenen en samen met de patiënt besluiten te nemen over de (operatieve) behandeling, waarbij innovatie en geavanceerde beeldvorming een steeds grotere…”

Over mij

Het is een voorrecht dit vak te mogen uitoefenen en samen met de patiënt besluiten te nemen over de (operatieve) behandeling van zijn of haar aandoening, waarbij innovatie en geavanceerde beeldvorming een steeds grotere rol gaan spelen. Tevens gebruik ik wetenschappelijk onderzoek om de kwaliteit van zorg te verbeteren en patiënt -specifieke behandelingen te ontwikkelen, steeds meer toegespitst op de individuele patiënt.

​BIG-registratie: 79912532301

Aandachtsgebieden

  • Neuro-oncologie
  • wakkere hersenoperaties
  • traumatologie
  • wetenschappelijk onderzoek.

Studie & opleiding

  •  2020 – heden
  Neurochirurg
Elisabeth-TweeSteden Ziekenhuis, Tilburg
Bernhoven Ziekenhuis, Uden
  •  2013 – 2020
  Opleiding neurochirurgie
Universitair Medisch Centrum Utrecht, Utrecht
Elisabeth-TweeSteden Ziekenhuis, Tilburg
  • 2010 – 2014
  Promotietraject resulterend in het proefschrift “Continued   bleeding following acute intracerebral Hemorrhage”
Harvard Medical School, Boston, Verenigde Staten
Universiteit Utrecht
  • 2003 – 2010
  Geneeskunde  Universiteit Utrecht
  •  2002 – 2003
  Psychologie  Universiteit Utrecht

Onderzoek & publicaties

https://pubmed.ncbi.nlm.nih.gov/?term=brouwers+hb

  1. Singh SD, Schreuder FHBM, van Nieuwenhuizen KM, Jolink WM, Senff JR, Goldstein JN, Boogaarts J, Klijn CJM, Rinkel GJE, Brouwers HB. Secondary Hematoma Evacuation and Outcome After Initial Conservative Approach for Patients with Cerebellar Hematoma Larger than 3 cm. Neurocritical Care 2021 10.1007/s12028-021-01203-6.
  2. Singh SD, Brouwers HB, Senff JR, Pasi M, Goldstein J, Viswanathan A, Klijn CJM, Rinkel GJE. Haematoma evacuation in cerebellar intracerebral haemorrhage: systematic review. J Neurol Neurosurg Psychiatry 2020;91:82-87.
  3. Uniken Venema SM, Marini S, Brouwers HB, Morotti A, Woo D, Anderson CD, Rosand J. Associations of Radiographic Cerebral Small Vessel Disease with Acute Intracerebral Hemorrhage Volume, Hematoma Expansion, and Intraventricular Hemorrhage. Neurocrit Care 2020;32:383-391.
  4. van Doormaal TPC, Germans MR, Sie M, Brouwers HB, Fierstra J, Depauw PRAM, Robe PA, Regli L. Single-Arm, Open-Label, Multicenter Study to Evaluate the Safety and Performance of Dura Sealant Patch in Reducing Cerebrospinal Fluid Leakage Following Elective Cranial Surgery: The ENCASE Trial Study Protocol. Neurosurgery 2020;86:E203-E208.
  5. Uniken Venema SM, Marini S, Lena UK, Morotti A, Jessel M, Moomaw CJ, Kourkoulis C, Testai FD, Kittner SJ, Brouwers HB, James ML, Woo D, Anderson CD, Rosand J. Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage. Stroke 2019;50:2722-2728.
  6. Jochems D, van Wessem KJP, Houwert RM, Brouwers HB, Dankbaar JW, van Es MA, Geurts M, Slooter AJC, Leenen LPH. Outcome in Patients with Isolated Moderate to Severe Traumatic Brain Injury. Crit Care Res Pract 2018:3769418.
  7. Simjian T, Muskens IS, Lamba N, Yunusa I, Wong K, Veronneau R, Kronenburg A, Brouwers HB, Smith TR, Mekary RA, Broekman MLD. Dexamethasone Administration and Mortality in Patients with Brain Abscess: A Systematic Review and Meta-Analysis. World Neurosurg 2018;257-263.
  8. de Boorder T, Brouwers HB, Noordmans HJ, Woerdeman PA, Han KS, Verdaasdonk RM. Thulium laser-assisted endoscopic third ventriculostomy: Determining safe laser settings using in vitro model and 2 year follow-up results in 106 patients. Lasers Surg Med. 2017 Dec 7 [Epub ahead of print]
  9. Morotti A, Boulouis G, Romero JM, Brouwers HB, Jessel MJ, Vashkevich A, Schwab K, Afzal MR, Cassarly C, Greenberg SM, Martin RH, Qureshi AI, Rosand J, Goldstein JN; ATACH-II and NETT investigators. Blood pressure reduction and noncontrast CT markers of intracerebral hemorrhage expansion. Neurology 2017;89:548-554.
  10. Morotti A, Brouwers HB, Romero JM, Jessel MJ, Vashkevich A, Schwab K, Afzal MR, Cassarly C, Greenberg SM, Martin RH, Qureshi AI, Rosand J, Goldstein JN; Antihypertensive Treatment of Acute Cerebral Hemorrhage II and Neurological Emergencies Treatment Trials Investigators. Intensive Blood Pressure Reduction and Spot Sign in Intracerebral Hemorrhage: A Secondary Analysis of a Randomized Clinical Trial. JAMA Neurol 2017;74:950-960.
  11. Anderson CD, Falcone GJ, Phuah CL, Radmanesh F, Brouwers HB, Battey TW, Biffi A, Peloso GM, Liu DJ, Ayres AM, et al.; On Behalf of the Global Lipids Genetics Consortium and International Stroke Genetics Consortium. Genetic variants in CETP increase risk of intracerebral hemorrhage. Ann Neurol 2016;80:730-740.
  12. Boulouis G, van Etten ES, Charidimou A, Auriel E, Morotti A, Pasi M, Haley KE, Brouwers HB, Ayres AM, Vashkevich A, Jessel MJ, Schwab KM, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN, Gurol ME. Association of Key Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease With Hematoma Volume and Expansion in Patients With Lobar and Deep Intracerebral Hemorrhage. JAMA Neurol 2016;73:1440-1447.
  13. Boulouis G, Morotti A, Brouwers HB, Charidimou A, Jessel MJ, Auriel E, Pontes-Neto O, Ayres A, Vashkevich A, Schwab KM, Rosand J, Viswanathan A, Gurol ME, Greenberg SM, Goldstein JN. Noncontrast Computed Tomography Hypodensities Predict Poor Outcome in Intracerebral Hemorrhage Patients. Stroke 2016;47:2511-2516.
  14. Boulouis G, Morotti A, Brouwers HB, Charidimou A, Jessel MJ, Auriel E, Pontes-Neto O, Ayres A, Vashkevich A, Schwab KM, Rosand J, Viswanathan A, Gurol ME, Greenberg SM, Goldstein JN. Association Between Hypodensities Detected by Computed Tomography and Hematoma Expansion in Patients With Intracerebral Hemorrhage. JAMA Neurol 2016;73:961-968.
  15. Morotti A, Romero JM, Jessel MJ, Brouwers HB, Gupta R, Schwab K, Vashkevich A, Ayres A, Anderson CD, Gurol ME, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. Effect of CTA Tube Current on Spot Sign Detection and Accuracy for Prediction of Intracerebral Hemorrhage Expansion. AJNR Am J Neuroradiol 2016;37:1781-1786.
  16. Brouwers HB, Dowlatshahi D, Demchuk AM, Hill MD, Aviv RI, Ufholz LA, Reaume M, Wintermark M, Hemphill JC 3rd, Murai Y, Wang Y, Zhao X, Wang Y, Li N, Sorimachi T, Matsumae M, Steiner T, Rizos T, Greenberg SM, Romero JM, Rosand J, Goldstein JN, Sharma M. Predicting Intracerebral Hemorrhage Growth With the Spot Sign: The Effect of Onset-to-Scan Time. Stroke 2016;47:695-700.
  17. Boland T, Henderson GV, Gibbons FK, Brouwers HB, Greenberg SM, Raffeld MR, Kourkoulis CE, Rosand J, Christopher KB. Hypernatremia at hospital discharge and out of hospital mortality following primary intracerebral hemorrhage. Neurocrit Care 2016;25:110-116.
  18. Morotti A, Jessel MJ, Brouwers HB, Falcone GJ, Schwab K, Ayres AM, Vashkevich A, Anderson CD, Viswanathan A, Greenberg SM, Gurol ME, Romero JM, Rosand J, Goldstein JN. CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage. Neurocrit Care 2016;25:79-85.
  19. Heit JJ, Gonzalez RG, Sabbag D, Brouwers HB, Ordonez Rubiano EG, Schaefer PW, Hirsch JA, Romero JM. Detection and characterization of intracranial aneurysms: a 10-year multidetector CT angiography experience in a large center. J Neurointerv Surg 2016;8:1168-1172.
  20. Brouwers HB, Battey TW, Musial HH, Ciura VA, Falcone GJ, Ayres AM, Vashkevich A, Schwab K, Viswanathan A, Anderson CD, Greenberg SM, Pomerantz SR, Ortiz CJ, Goldstein JN, Gonzalez RG, Rosand J, Romero JM. Rate of Contrast Extravasation on CTA Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage. Stroke 2015;46:2498-2503.
  21. Brouwers HB, van Nieuwenhuizen KM, Klijn CJM. CT angiography Spot Sign in Intracerebral Hemorrhage. Tijdschrift voor Neurologie en Neurochirurgie 2015;116:118-120.
  22. Ciura VA, Brouwers HB, Pizzolato R, Ortiz CJ, Rosand J, Goldstein JN, Greenberg SM, Pomerantz SR, Gonzalez RG, Romero JM. Spot Sign on 90-Second Delayed Computed Tomography Angiography Improves Sensitivity for Hematoma Expansion and Mortality: Prospective Study. Stroke 2014;45:3293-3297.
  23. Falcone GJ, Radmanesh F, Brouwers HB, Battey TW, Devan WJ, Valant V, Raffeld MR, Chitsike LP, Ayres AM, Schwab K, et al.; On Behalf of the International Stroke Genetics Consortium. APOE ε variants increase risk of warfarin-related intracerebral hemorrhage. Neurology 2014;83:1139-1146.
  24. Brouwers HB, Raffeld MR, van Nieuwenhuizen KM, Falcone GJ, Ayres AM, McNamara KA, Schwab K, Romero JM, Velthuis BK, Viswanathan A, Greenberg SM, Ogilvy CS, van der Zwan A, Rinkel GJE, Goldstein JN, Klijn CJM, Rosand J. CT Angiography Spot Sign in Intracerebral Hemorrhage Predicts Active Bleeding During Surgery. Neurology 2014;83:883-889.
  25. Radmanesh F, Falcone GJ, Anderson CD, Battey TW, Ayres AM, Vashkevich A, McNamara KA, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Goldstein JN, Rosand J, Brouwers HB. Predictors of the CT angiography spot sign in deep and lobar intracerebral hemorrhage. Stroke 2014;45:1833-1835.
  26. Woo D, Falcone GJ, Devan WJ, Brown WM, Biffi A, Howard TD, Anderson CD, Brouwers HB, Valant V, Battey TW, et al; On behalf of the International Stroke Genetics Consortium. Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage. Am J Hum Genet 2014;94:511-521.
  27. Boulouis G, Dumas A, Betensky RA, Brouwers HB, Fotiadis P, Vashkevich A, Ayres A, Schwab K, Romero JM, Smith EE, Viswanathan A, Goldstein JN, Rosand J, Gurol ME, Greenberg SM. Anatomic Pattern of Intracerebral Hemorrhage Expansion: Relation to CT Angiography Spot Sign and Hematoma Center. Stroke 2014;45:1154-1156.
  28. Brouwers HB, Chang Y, Falcone GJ, Cai X, Ayres AM, Battey TW, Vashkevich A, McNamara KA, Valant V, Schwab K, Orzell SC, Bressette L, Feske SK, Rost NS, Romero JM, Viswanathan A, Chou SH-Y, Greenberg SM, Rosand J, Goldstein JN. Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage. JAMA Neurol 2014;71:158-164.
  29. Romero JM, Brouwers HB, Lu J, Delgado Almandoz JE, Kelly H, Heit J, Goldstein JN, Rosand J, Gonzalez RG. Prospective Validation of the Computed Tomographic Angiography Spot Sign Score for Intracerebral Hemorrhage. Stroke 2013;44:3097-3102.
  30. Falcone GJ, Brouwers HB, Biffi A, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab KM, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Warfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage. Neurocritical Care 2014;21:192-199.
  31. Falcone GJ, Biffi A, Brouwers HB, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Predictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage. JAMA Neurol 2013;70:988-994.
  32. Brouwers HB, Backes D, Kimberly WT, Schwab K, Romero JM, Velthuis BK, Klijn CJ, Ogilvy CS, Regli L, Greenberg SM, Rosand J, Rinkel GJ, Goldstein JN. CTA Spot Sign Does Not Predict Case Fatality in Aneurysmal Subarachnoid Hemorrhage with Intraparenchymal Extension. Stroke 2013;44:1590-1594.
  33. Brouwers HB, Greenberg SM. Hematoma Expansion Following Acute Intracerebral Hemorrhage. Cerebrovasc Dis 2013;35:195-201.
  34. Falcone GJ, Biffi A, Devan WJ, Brouwers HB, Anderson CD, Valant V, Ayres AM, Schwab K, Rost NS, Goldstein JN, et al.; On behalf of the GOCHA Investigators. Burden of Blood Pressure-Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage. Stroke 2013;44:321-326.
  35. Brouwers HB, Regli L. The CT angiography spot sign: to operate or not to operate? Neurosurg Rev 2013;36:341-348.
  36. Goldstein JN, Brouwers HB, Romero JM, McNamara KA, Schwab K, Greenberg SM, Rosand J. SCORE-IT: The Spot Sign Score in Restricting ICH Growth – An ATACH-II Ancillary Study. J Vasc Interv Neurol 2012;5:20-25.
  37. Falcone GJ, Brouwers HB, Rosand J. Risk of Intracranial Hemorrhage with Protease-activated Receptor-1 Antagonists. Stroke 2012;43:3158-3159.
  38. Brouwers HB, Goldstein JN, Romero JM, Rosand J. Clinical Applications of the CT Angiography Spot Sign in Acute Intracerebral Hemorrhage: A Review. Stroke 2012;43:3427-3432.
  39. Brouwers HB, Falcone GJ, McNamara KA, Ayres AM, Oleinik A, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. CTA Spot Sign Predicts Hematoma Expansion in Patients with Delayed Presentation After Intracerebral Hemorrhage. Neurocrit Care 2012;17:421-428.
  40. Brouwers HB, Biffi A, McNamara KA, Ayres AM, Valant V, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. Apolipoprotein E Genotype Is Associated With CT Angiography Spot Sign in Lobar Intracerebral Hemorrhage. Stroke 2012;43:2120-2125.
  41. Brouwers HB, Biffi A, Ayres AM, Schwab K, Cortellini L, Romero JM, Rost NS, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. APOE Genotype Predicts Hematoma Expansion in Lobar Intracerebral Hemorrhage. Stroke 2012;43:1490-1495.
  42. Brouwers HB, Goldstein JN. Therapeutic strategies in acute intracerebral hemorrhage. Neurotherapeutics 2012;9:87-98.
  43. Delgado Almandoz JE, Kelly HR, Schaefer PW, Brouwers HB, Yoo AJ, Stone MJ, Goldstein JN, Rosand J, Lev MH, Gonzalez RG, Romero JM. CT angiography spot sign predicts in-hospital mortality in patients with secondary intracerebral hemorrhage. J Neurointerv Surg 2012;4:442-447.
  44. Delgado Almandoz JE, Yoo AJ, Stone MJ, Schaefer PW, Oleinik A, Brouwers HB, Goldstein JN, Rosand J, Lev MH, Gonzalez RG, Romero JM. The spot sign score in primary intracerebral hemorrhage identifies patients at highest risk of in-hospital mortality and poor outcome among survivors. Stroke 2010;41:54-60.

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